Weight Loss Medicine and Prescriptions - Qnexa

Qnexa (Q-NEX-uh) is a once-a-day, proprietary, oral, controlled-release formulation of low dose phentermine and topiramate, which is believed to address both appetite and satiety - the two main mechanisms that impact eating behavior - in one capsule. Qnexa, an investigational drug, is being developed to address weight loss. In phase 2 and 3 clinical data to date, Qnexa has demonstrated significant weight loss, glycemic control, and improvement in cardiovascular risk factors.

Qnexa is currently being evaluated in clinical studies at 3 different doses:

  • Full strength: 92mg of topiramate/15 mg of phentermine

  • Mid dose: 46mg of topiramate/7.5mg of phentermine

  • Low dose: 23 mg of topiramate/3.75mg of phentermine

the first of the three phase 3 studies, evaluated 756 obese patients over 28 weeks at 32 sites.  EQUIP and CONQUER were 56-week studies; EQUIP evaluated 1,267 morbidly obese patients with or without co-morbidities and CONQUER evaluated 2,487 overweight and obese patients with at least two co-morbid condition.

ADVERSE REACTIONS

According to the clinical study on Qnexa, the most common side effects are headaches, dry mouth, constipation, altered taste, and nausea.

The main side effects reported during testing phases where: dry mouth, a tingling in the fingers and toes, and constipation

About VIVUS

VIVUS is a biopharmaceutical company developing innovative, next-generation therapies to address unmet needs in obesity, diabetes and sexual health. The company's lead product in clinical development, Qnexa(TM), has recently completed phase 3 clinical trials for the treatment of obesity. Qnexa is also in phase 2 clinical development for the treatment of type 2 diabetes. In the area of sexual health, VIVUS is in phase 3 development with avanafil, a potentially best-in-class PDE5 inhibitor, and in phase 2 development of Luramist(TM) for the treatment of hypoactive sexual desire disorder (HSDD) in women. MUSE(R) (alprostadil), a first generation therapy for the treatment of ED, is already on the market and generating revenue for VIVUS. For more information about the company, please visit www.vivus.com.

How much will Qnexa cost?

 

The exact cost of Qnexa is not known. Also unknown is whether insurance plans will cover Qnexa. Prescription pills tend to be very expensive. Phentermine prescription pills usually cost between $100 and $200. This does not include the doctor’s visit to get the prescription. Doctors’ visits usually cost $200 plus.

Source: http://www.slimmingpillsreview.com/qnexa/

Effectiveness compared with current drugs

Qnexa achieved significantly greater weight loss as compared to placebo and each of the product's active ingredients alon


Qnexa achieved a placebo-adjusted weight loss of 20.1 pounds at week 24 This is nearly twice the weight loss achieved with a high dose of Sanofi-Aventis' Acomplia (rimonabant) at week 52 (10.6 pounds) in a similar group of patients

Weight loss with Qnexa had not plateaued at 24 weeks as has been observed with other obesity therapeutics in development

Only one patient dropped out of the Qnexa study arm due to side effects (2%) with only 8% total non-completers for any reason. Dropouts for topiramate alone were 14%, phentermine alone 24%, and placebo 38%, indicating how well Qnexa was tolerated in this population.

VIVUS is currently undertaking additional formulation development for Qnexa to increase the convenience of patient dosing. Ultimately, the final Qnexa formulation will offer once-a-day, oral dosing utilizing advanced sustained and controlled release technology which will provide precision release of each active ingredient in order to maximize efficacy and tolerability.

Source: http://www.emaxhealth.com/1/109/27559/vivus-presents-qnexa-obesity-treatment.html

Dosage

Qnexa (Q-NEX-uh) is a once-a-day, proprietary, oral, controlled-release formulation of low dose phentermine and topiramat.

Qnexa Side Effects

According to the clinical study on Qnexa, the most common side effects are headaches, dry mouth, constipation, altered taste, and nausea.

The main side effects reported during testing phases where: dry mouth, a tingling in the fingers and toes, and constipation

Source:http://www.slimmingpillsreview.com/qnexa/

              http://en.wikipedia.org/wiki/Qnexa

Are you Eligible to have Qnexa?

As of now pregnant women or women who plan on becoming pregnant are not eligible to participate in the Qnexa clinical trials. Women are advised to use and agree to use two forms of birth control during the study. Subjects that become pregnant during the study period will immediately discontinue study medication.

How much will Qnexa cost?

The exact cost of Qnexa is not known. Also unknown is whether insurance plans will cover Qnexa. Prescription pills tend to be very expensive. Phentermine prescription pills usually cost between $100 and $200. This does not include the doctor’s visit to get the prescription. Doctors’ visits usually cost $200 plus.

Source: http://www.slimmingpillsreview.com/qnexa/